New miRNAs cloned from neuroblastoma
نویسندگان
چکیده
منابع مشابه
Identification of miRNAs contributing to neuroblastoma chemoresistance
BACKGROUND The emergence of the role of microRNAs (miRNAs) in exacerbating drug resistance of tumours is recently being highlighted as a crucial research field for future clinical management of drug resistant tumours. The purpose of this study was to identify dys-regulations in expression of individual and/or networks of miRNAs that may have direct effect on neuroblastoma (NB) drug resistance. ...
متن کاملThe role of epigenetics and miRNAs in neuroblastoma development
Introduction Neuroblastoma (NB) is an often fatal pediatric cancer that arises from the precursor cells of the sympathetic nervous system. 13-Cis retinoic acid is used to treat high-risk disease. A derivative, all-trans-retinoic acid (ATRA) causes genome-wide demethylation in NB cells by up-regulating miRNAs such as miR-152 and miR-26a/b which are predicted to target the methyltransferases DNMT...
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Restoration of the antitumor activity of p53 could offer a promising approach for the treatment of neuroblastoma. MicroRNAs (miRNAs) are important mediators of p53 activity, but their role in the p53 response has not yet been comprehensively addressed in neuroblastoma. Therefore, we set out to characterize alterations in miRNA expression that are induced by p53 activation in neuroblastoma cells...
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Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important. MicroRNAs are one of the most important biomarkers which attract the attention of many researchers due to a variety of reasons, including their non-invasive nature; these molecules are a group of non-...
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microRNAs (miRNAs) are a class of small RNAs, 21-25 nucleotides (nts) long with single-stranded RNA. miRNA targets the sequences of messenger RNA (mRNA) through incomplete base-pairing of the target sequence. The incomplete pairing of miRNA to mRNA triggers either translational repression or epigenetically mediated transcriptional gene silencing (TGS). miRNA and RNA silencing in mammalian cells...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2008
ISSN: 1471-2164
DOI: 10.1186/1471-2164-9-52